abstract：BACKGROUND AND AIMS:Status 1A patients are prioritized over end-stage liver disease (ESLD) for liver transplantation (LT). ESLD patients with high MELD may have higher waitlist mortality than Status 1A patients, and may require LT more urgently. METHODS:Using United Network for Organ Sharing registry data, we retrospe...

journal_title：Hepatology international

authors： Ahn J,Bhuket T,Mosadeghi S,Frenette C,Liu B,Wong RJ

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND AND AIM:Relationships between circulating microRNA-122 (miR-122) and histological features of nonalcoholic fatty liver disease (NAFLD) are unclear. METHODS:The impact of serum miR-122 levels for histological features and hepatocellular carcinoma (HCC) was investigated in 305 Japanese patients with histologi...

journal_title：Hepatology international

authors： Akuta N,Kawamura Y,Suzuki F,Saitoh S,Arase Y,Kunimoto H,Sorin Y,Fujiyama S,Sezaki H,Hosaka T,Kobayashi M,Suzuki Y,Kobayashi M,Ikeda K,Kumada H

更新日期：2016-07-01 00:00:00

abstract：:Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. ALD encompasses a spectrum of disorders including asymptomatic steatosis, steatohepatitis, fibrosis, cirrhosis and its related complications, and the acute-on-chronic state of alcoholic hepatitis. While multidisciplina...

journal_title：Hepatology international

authors： Arsene D,Farooq O,Bataller R

更新日期：2016-07-01 00:00:00

abstract：:Along with the obesity epidemic, the prevalence of nonalcoholic fatty liver disease (NAFLD) has increased exponentially. The histological disease spectrum of NAFLD ranges from bland fatty liver (hepatic steatosis), to the concomitant presence of inflammation and ballooning which defines nonalcoholic steatohepatitis (N...

journal_title：Hepatology international

authors： Eslam M,George J

更新日期：2016-05-01 00:00:00

abstract：:Worldwide, some 240 million people have chronic hepatitis B virus (HBV), with the highest rates of infection in Africa and Asia. Our understanding of the natural history of HBV infection and the potential for therapy of the resultant disease is continuously improving. New data have become available since the previous ...

journal_title：Hepatology international

authors： Sarin SK,Kumar M,Lau GK,Abbas Z,Chan HL,Chen CJ,Chen DS,Chen HL,Chen PJ,Chien RN,Dokmeci AK,Gane E,Hou JL,Jafri W,Jia J,Kim JH,Lai CL,Lee HC,Lim SG,Liu CJ,Locarnini S,Al Mahtab M,Mohamed R,Omata M,Park J,

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Cholecystectomy is routinely performed at most transplant centers during living donor liver transplantation (LDLT). This study was performed to evaluate the feasibility of liver graft procurement with donor gallbladder preservation in LDLT. METHODS:Eighty-nine LDLTs (from June 2006 to Dec 2012) were retrospe...

journal_title：Hepatology international

authors： Dong JH,Ye S,Duan WD,Ji WB,Liang YR

更新日期：2015-10-01 00:00:00

abstract：:The presence of hepatic encephalopathy (HE) within 4 weeks is part of the criteria for defining acute-on-chronic liver failure (ACLF). The pathophysiology of HE is complex, and hyperammonemia and cerebral hemodynamic dysfunction appear to be central in the pathogenesis of encephalopathy. Recent data also suggest that ...

journal_title：Hepatology international

authors： Lee GH

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the association of the Laennec staging system with degree of cirrhosis, clinical stage and liver function. METHODS:Liver biopsy was performed for 30 patients with hepatitis B cirrhosis to test the content of hydroxyproline in hepatic tissue, judge the degree of cirrh...

journal_title：Hepatology international

authors： Wang W,Li J,Pan R,A S,Liao C

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The progression of HBsAg-positive chronic hepatitis is insidious and unpredictable. Identification of factors leading to either a benign or more serious clinical outcome may assist in decision making for antiviral therapy. METHODS:From 1989 to 1998, 130 untreated patients with chronic hepatitis wer...

journal_title：Hepatology international

authors： Tong MJ,Huynh TT,Siripongsakun S,Chang PW,Tong LT,Ha YP,Mena EA,Weissman MF

更新日期：2015-10-01 00:00:00

abstract：:Hepatitis B virus (HBV) reactivation with hepatic decompensation leading to acute on chronic liver failure is not uncommon. It is associated with high mortality of up to 30-70%. Prognostic factors for mortality include high bilirubin level, more prolonged prothrombin time, low platelet count and presence of pre-existi...

journal_title：Hepatology international

authors： Yuen MF

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND AIM:Acute kidney injury (AKI), as defined by the Acute Kidney Injury Network, has been widely investigated in decompensated liver cirrhosis patients. AKI is frequently progressive and independently associated with mortality in these patients. However, in the Asia-Pacific region, the majority of cases of ...

journal_title：Hepatology international

authors： Huang Z,Lin C,Fang J,Wang N,Zhou R,Pan C

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The association of obstructive sleep apnea (OSA) with nonalcoholic fatty liver disease (NAFLD) has only been studied in selected subgroups such as the morbidly obese. We aimed to determine the prevalence and effect of OSA on NAFLD and vice versa in unselected patients attending the outpatient department. ME...

journal_title：Hepatology international

authors： Agrawal S,Duseja A,Aggarwal A,Das A,Mehta M,Dhiman RK,Chawla Y

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Cytokines have been reported to be involved in the cirrhosis and hepatic encephalopathy (HE). Many aspects on the correlation between minimal HE (MHE) and cytokine levels were still unclear. METHODS:Two hundred eighty-nine HBV-infected cirrhotic patients were grouped: non MHE (n = 156), MHE (n...

journal_title：Hepatology international

authors： Li W,Li N,Wang R,Li Q,Wu H

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Hepatitis C (HCV) is the predominant cause of chronic liver disease in the USA and is increasingly recognized as a common cause of liver disease in China. Studies of HCV patients in the US found major gaps in knowledge but little is known about HCV knowledge among patients in China. METHODS:We conducted a s...

journal_title：Hepatology international

authors： Wu E,Chen X,Guan Z,Cao C,Rao H,Feng B,Chan M,Fu S,Lin A,Wei L,Lok AS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The life cycle of hepatitis C virus (HCV) is tightly associated with host lipoprotein metabolic pathways. Apolipoprotein is present on the outer surface of lipoprotein particles and plays an important role in lipoprotein metabolism. We aimed to elucidate the influence of chronic HCV infection on serum apolip...

journal_title：Hepatology international

authors： Seki N,Sugita T,Aida Y,Itagaki M,Ishiguro H,Sutoh S,Abe H,Tsubota A,Matsushima M,Aizawa Y

更新日期：2014-10-01 00:00:00

abstract：:The prognosis of advanced hepatocellular carcinoma (HCC) remains poor. For patients with advanced HCC, the multikinase inhibitor sorafenib is recommended as the current standard of care. In contrast, hepatic arterial infusion chemotherapy (HAIC) is one of the recommended treatments in Japan. However, in Japan, the use...

journal_title：Hepatology international

authors： Yamasaki T,Saeki I,Sakaida I

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:Ethanol binge augments liver injury after chronic ethanol consumption in humans, but the mechanism behind the enhanced liver injury by ethanol binge is not known. In this study we used a clinically relevant rat model in which liver injury is amplified by binge after chronic ethanol treatment and investigated th...

journal_title：Hepatology international

authors： Aroor AR,Restrepo RJ,Kharbanda KK,Shukla SD

更新日期：2014-09-01 00:00:00

abstract：PURPOSE:The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party to develop a consensus cost-effectiveness model for treatment of Hepatitis B in Asia Pacific countries in March 2010. METHODS:The working party consisted of expert hepatologists, virologists and epidemiolog...

journal_title：Hepatology international

authors： Dan YY,Wong JB,Hamid SS,Han KH,Jia JD,Liu CJ,Piratvisuth T,Lok AS,Lim SG

更新日期：2014-07-01 00:00:00

abstract：PURPOSE:Clevudine 30 mg showed potent antiviral activity with a marked post-treatment antiviral effect. However, long-term treatment with clevudine monotherapy induced resistance and myopathy in some cases. The objective of this study is to evaluate the preliminary efficacy and safety of the combination of clevudine 20...

journal_title：Hepatology international

authors： Tak WY,Yang JM,Kim BI,Baik SK,Cheon GJ,Byun KS,Kim DY,Yoo BC

更新日期：2014-05-25 00:00:00

abstract：PURPOSE:Interferon-induced graft dysfunction (IGD) is a poorly defined, unrecognized, but potentially serious condition for patients receiving antiviral drugs after liver transplantation for hepatitis C. METHODS:We evaluated the characteristics of 80 patients who received pegylated interferon-based antiviral treatment...

journal_title：Hepatology international

authors： Ikegami T,Wang H,Yoshizumi T,Toshima T,Aishima S,Fukuhara T,Furusyo N,Kotoh K,Shimoda S,Shirabe K,Maehara Y

更新日期：2014-04-01 00:00:00

abstract：:Immunomodulatory cell therapy as a complement to standard pharmacotherapy represents a novel approach to solid organ allograft acceptance. This methodology may allow for a reduced dose of immunosuppressive drug to be administered and thus attenuate the severe side effects associated with long-term immunosuppression su...

journal_title：Hepatology international

authors： Benseler V,Obermajer N,Johnson CL,Soeder Y,Dahlke MD,Popp FC

更新日期：2014-04-01 00:00:00

abstract：AIM:Tamibarotene is a synthetic retinoid expected to inhibit tumor-cell proliferation and to induce apoptosis by selective interaction with retinoic acid receptor α/β. We conducted an open-label phase I/II study to determine the maximum tolerated dose (MTD) and recommended dose (RD), and to evaluate the pharmacokinetic...

journal_title：Hepatology international

authors： Kanai F,Obi S,Fujiyama S,Shiina S,Tamai H,Mochizuki H,Koike Y,Imamura J,Yamaguchi T,Saida I,Yokosuka O,Omata M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Initial presentation of hepatocellular carcinoma (HCC) at an advanced stage in patients under a regular surveillance program is a devastating problem. AIMS:We assessed the prevalence and factors associated with this surveillance failure. METHODS:A total of 304 HCC patients who received regular surveillance...

journal_title：Hepatology international

authors： Sinn DH,Yi J,Choi MS,Choi D,Gwak GY,Paik YH,Lee JH,Koh KC,Paik SW,Yoo BC

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:Despite improvements in immunosuppressive therapy, acute cellular rejection (ACR) remains an important cause of graft loss in patients undergoing liver transplantation. Recently, associations between cytokine gene polymorphisms in recipients and the occurrence of ACR have been reported. However, most studies di...

journal_title：Hepatology international

authors： Kamei H,Masuda S,Nakamura T,Ishigami M,Fujimoto Y,Ogura Y,Oike F,Takada Y,Hamajima N

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To compare the efficacy of entecavir (ETV) monotherapy up to 4 years in nucleos(t)ide analog (NA)-experienced and -naïve subjects. METHODS:One hundred sixty NA-experienced and 282 naïve chronic hepatitis B patients who were treated with ETV were enrolled. Of the 160 NA-experienced patients, 49 had prior lamivu...

journal_title：Hepatology international

authors： Chen CH,Hu TH,Hung CH,Lu SN,Wang JH,Chang MH,Changchien CS,Lee CM

更新日期：2013-07-01 00:00:00

abstract：PURPOSE:To elucidate the efficiency of contrast-enhanced ultrasonography alone and in combination with other noninvasive models for grading hepatic fibrosis. METHODS:This prospective study included 74 patients with four grades (F1-F4) of chronic liver disease (17, 20, 18, and 19 patients, respectively). Diagnostic per...

journal_title：Hepatology international

authors： Tawada A,Maruyama H,Kamezaki H,Shimada T,Ishibashi H,Takahashi M,Kanda T,Fujiwara K,Imazeki F,Yokosuka O

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant neoplasms worldwide. The p53 gene is frequently mutated in some histological subtypes of HCC. The role of p53 mutations and polymorphic variant of codon 72 in the prognosis of disease is still unclear. The p53 tumor suppressor gene Arg72Pro p...

journal_title：Hepatology international

authors： Jia S,Tang W,Luo Y

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatit...

journal_title：Hepatology international

authors： Kakazu E,Kondo Y,Ninomiya M,Kimura O,Nagasaki F,Ueno Y,Shimosegawa T

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:We investigated whether the combined presence and evolution of hepatitis B virus (HBV) mutant strains in the hepatitis B e antigen (HBeAg)-positive status can predict clinical outcomes after HBeAg seroconversion. METHODS:One hundred and eighty-six patients with spontaneous HBeAg seroconversion were enrolled in...

journal_title：Hepatology international

authors： Chen CH,Lee CM,Wang JH,Hu TH,Hung CH,Changchien CS,Lu SN

更新日期：2013-06-01 00:00:00

abstract：:In patients with chronic hepatitis B (CHB), liver fibrosis assessment is essential not only for determining prognosis but also for identifying patients who should receive treatment. Liver biopsy is limited by its invasiveness and sampling error. To explore effective non-invasive methods for liver fibrosis assessment, ...

journal_title：Hepatology international

authors： Chen YP,Peng J,Hou JL

更新日期：2013-06-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is endemic in the Asian-Pacific region, and reactivation of HBV post-cancer chemotherapy has become an emerging clinical challenge. Patients with detectable serum HBV DNA before chemotherapy and those receiving intensive chemotherapy are particularly at a risk of HBV reactivat...

journal_title：Hepatology international

authors： Liu CJ,Chen PJ,Chen DS,Kao JH

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:All previous studies reported the benefit of antibiotic prophylaxis in cirrhotic patients with either a mixture of nonvariceal and variceal bleeding or variceal bleeding alone. Reports on sole peptic ulcers bleeding are lacking. We aimed to assess the effect of antibiotic prophylaxis in cirrhotic patients with ...

journal_title：Hepatology international

authors： Yang SC,Wu KL,Wang JH,Lee CH,Kuo YH,Tai WC,Chen CH,Chiou SS,Lu SN,Hu TH,Changchien CS,Chuah SK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND AIMS:A discrepancy in virological and biochemical responses may occur throughout interferon-based therapy for hepatitis C virus (HCV). We aimed to explore the risk, associated factors, potential mechanisms, and impact on the treatment outcome of the discrepancy. SUBJECTS AND METHODS:Consecutive 496, chr...

journal_title：Hepatology international

authors： Chen CH,Huang JF,Huang CF,Yeh ML,Yang JF,Hsieh MY,Hou NJ,Lin ZY,Chen SC,Hsieh MY,Wang LY,Chuang WL,Dai CY,Yu ML

更新日期：2013-03-01 00:00:00

abstract：:Substantial advancements in the field of primary biliary cirrhosis (PBC) research have broadened our understanding of this enigmatic disease. Genome-wide studies have identified several new candidate genes involved in the immunoregulatory process, particularly those responsible for antigen presentation and lymphocyte ...

journal_title：Hepatology international

authors： Trivedi PJ,Cullen S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:There is much controversy surrounding the natural history of hepatitis C virus (HCV) infection. AIMS:The aim of this review was to review the natural history of HCV infection. METHODS:Published English literature was searched via pubmed and then reviewed. RESULTS:Approximately, 75-85% of HCV-infected pers...

journal_title：Hepatology international

authors： Sarin SK,Kumar M

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Type II mixed cryoglobulinemia (MC) is a systemic vasculitis usually associated with hepatitis C virus (HCV). The present trial was performed to investigate the efficacy of therapy with pegylated interferon alfa-2a (PEG-IFN alfa-2a) plus ribavirin in patients with HCV-related MC vasculitis and evaluate the fa...

journal_title：Hepatology international

authors： El Khayat HR,Fouad YM,Ahmad EA,El Amin H,Ismael F,Rizk A

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:There have been reports that radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) is as equally effective as surgical resection for the treatment of hepatocellular carcinoma (HCC). This study aimed to evaluate recurrence rate and risk factor of recurrence after RFA combined with TA...

journal_title：Hepatology international

authors： Kim JH,Yim HJ,Lee KG,Kim SY,Jung ES,Jung YK,Kim JH,Seo YS,Yeon JE,Lee HS,Um SH,Byun KS,Ryu HS

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Early prediction of lamivudine (LAM) response by individualized monitoring of serum HBV DNA like roadmap concept, and investigation of the outcome after LAM discontinuation in renal transplant recipients (RTRs) with chronic hepatitis B (CHB). METHODS:We conducted a study on 19 RTRs with HBV infection receiv...

journal_title：Hepatology international

authors： Hu TH,Tsai MC,Chen YT,Chien YS,Hung CH,Chen TC,Tseng PL,Chang KC,Yen YH

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Possible serologic activity after hepatitis B surface antigen (HBsAg) seroclearance documented by conventional assays in chronic hepatitis B (CHB) has not been thoroughly investigated. METHODS:We determined the levels of serum hepatitis B virus (HBV) DNA, hepatitis B core-related antigen (HBcrAg), and linea...

journal_title：Hepatology international

authors： Seto WK,Tanaka Y,Wong DK,Lai CL,Shinkai N,Yuen JC,Tong T,Fung J,Hung IF,Yuen MF

更新日期：2012-03-13 00:00:00

abstract：:More than 170 million people worldwide are infected with hepatitis C virus (HCV). A characteristic of this virus is a high tendency toward chronic infection. Several factors affect the viral outcome after infection. Among them, HCV-specific CD4 T cells are thought to play a crucial role in controlling viremia. Cumulat...

journal_title：Hepatology international

authors： Sugimoto K,Shiraki K

更新日期：2012-01-01 00:00:00